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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11766 | Eltanexor Z-isomer | KPT-8602 (Z-isomer) | Others |
Eltanexor Z-isomer exhibits different inhibitory effects on Z138, MM15, 3T3 cell lines, with IC50s of 100 nM-50 μM, < 100 nM, > 30 μM, respectively.Eltanexor Z-isomer is the less active isomer of KPT-8602. KPT-8602 is a... | |||
T11766L | Eltanexor | ONO-7706,KPT-8602,ATG-016 | Others |
Eltanexor (ONO-7706) is an orally active exportin-1 (XPO1) inhibitor. It has effective anti-leukemic activity. Eltanexor inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor causes ... | |||
T2280 | Endoxifen (Z-isomer) | Endoxifen Z-isomer | Estrogen Receptor/ERR , EGFR , Potassium Channel , Estrogen/progestogen Receptor , HER |
Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity. |